ea0041oc5.1 | Neuroendocrinology | ECE2016
Aflorei Elena Daniela
, Klapholz Benjamin
, Moderau Nina
, Baptista-Ribeiro Paulo
, Tapon Nic
, Brown Nick
, Stanewsky Ralf
, Korbonits Marta
Introduction: Tumours with aryl hydrocarbon receptor interacting (AIP) mutations often show an unusually aggressive and invasive clinical course as up to 80% of AIP positive pituitary adenomas have a certain degree of extrasellar extension. The exact mechanisms by which AIP inactivation promotes an aggressive behaviour remain unknown. The majority of adenohypophysis is composed of sinuous cords of epithelial cells and consequently, molecules that can induce remodellin...